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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2018 Sep 29;139:48–53. doi: 10.1016/j.prostaglandins.2018.09.008

Figure 2: Hypertensive stimuli leading to immune cell activation via IsoLG-protein adduct formation.

Figure 2:

Hypertensive stimuli including angiotensin II, sympathetic outflow and excess dietary salt lead to increased NADPH oxidase-dependent production of reactive oxygen species (ROS) by antigen presenting myeloid derived cells. This leads to oxidation of arachidonic acid and formation of IsoLG-protein adducts. These are immunogenic and activate antigen presenting cells to produce inflammatory cytokines including IL 1b, IL6 and IL23. These myeloid cells activate T cell to proliferate and produce inflammatory cytokines including IL-17A, TNF-α and IFN-γ which lead to hypertension.