Skip to main content
. Author manuscript; available in PMC: 2018 Dec 19.
Published in final edited form as: Mol Cell. 2016 Jul 28;63(5):898–911. doi: 10.1016/j.molcel.2016.06.034

Figure 4. Nucleotide Resolution Mapping of End Resection.

Figure 4.

(A) Top panel shows END-seq tracks surrounding an AsiSI DSB generated in Lig4−/− 53BP1−/−cycling pre-B cells. The accumulation of reads away from the DSB is indicative of end resection. Bottom panel shows the read coverage for RPA ChIP-seq for the same interval

(B) END-seq and RPA ChIP-seq reads for an AsiSI site distinct from that shown in (A). RPA ChIP-seq is not detectable above background for this site.

(C) End resection in G1-arrested versus cycling pre-B cells. The bottom track shows RPA ChIP-seq reads for the same interval. End resection is greater in cycling cells than arrested cells.

See also Figure S3.