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A) Activation of hMrgprX1 by CNF-Tx2, CNF-Vc1 and CNF-Vc1 analogues. The EC50 values for the peptides or analogues are indicated. * indicates a C-terminal amide B). Dose-dependent activation of hMrgprX1 by CNF-Vc1 and CNF-Vc1(7–18) each data point is the average of at least 3 experiments. CNF-Vc1(15–18) (red) does not activate the receptor at 10 µM. Error bars represent SEM.
