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. 2018 Dec 11;9:3037. doi: 10.3389/fmicb.2018.03037

Figure 2.

Figure 2

RNA-seq transcriptomics of S. aureus USA300 after 30 min of AGXX® stress. For RNA-seq transcriptomics, S. aureus USA300 was grown in RPMI medium and treated with 4.5 μg/ml AGXX® for 30 min. The gene expression profile under AGXX® stress is shown as ratio/intensity scatter plot (M/A-plot) which is based on differential gene expression analysis using DeSeq2. Colored symbols indicate significantly induced (red, orange, brown, blue, cyan, violet, green, yellow) or repressed (dark gray) transcripts (M ≥0.6 or ≤ -0.6; P ≤ 0.05). Light gray symbols denote transcripts with no fold-changes after AGXX® stress (P > 0.05). The PerR, TetR, HypR, QsrR, MhqR, CtsR, HrcA, CidR, CymR, Fur, CstR, CsoR, and Zur regulons are most strongly up-regulated under AGXX® stress. The transcriptome analysis was performed from three biological replicates. The RNA-seq expression data of all genes after AGXX® stress and their regulon classifications are listed in Tables S1, S2.