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. 2018 Dec 19;19:534. doi: 10.1186/s12859-018-2486-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 14 — Additional effect of p53 in IR response. a Expression patterns of selected DEGs. b Upregulated genes are enriched with genes related to p53 mediated response to DNA damage, especially apoptosis, and negative regulation of cell cycle. These genes are only induced by IR in cells with wildtype p53. One the other hand, p53 caused the relative downregulation of genes related to ribosome biogenesis, tRNA and rRNA processing, DNA replication, and protein folding. These genes are only upregulated by IR in Trp53−/−