Table 4.
Enriched transcription factor (TF) binding motifs
| Direction | Pathways | nGenes | adj.Pval |
|---|---|---|---|
| Down Regulated |
Tftargets:TF Target SP1 | 475 | 9.80E-23 |
| Tftargets:TF Target E2F-4 | 65 | 9.80E-23 | |
| TFactS E2F1 | 43 | 1.10E-16 | |
| TRRUST:TF Target E2F1 | 37 | 9.70E-15 | |
| RegNetwork:TF Target E2F4 | 127 | 1.20E-14 | |
| RegNetwork:TF Target E2F1 | 208 | 1.00E-13 | |
| TFactS E2F4 | 20 | 1.30E-12 | |
| RegNetwork:TF Target NFYA | 154 | 4.60E-09 | |
| TFactS E2F3 | 15 | 1.80E-08 | |
| Tftargets:TF Target TEAD1 | 33 | 1.90E-08 | |
| Tftargets:TF Target AP1 | 74 | 2.30E-08 | |
| TFactS E2F2 | 14 | 2.60E-08 | |
| Tftargets:TF Target TGIF1 | 34 | 3.30E-08 | |
| Tftargets:TF Target ZNF219 | 60 | 4.50E-08 | |
| Tftargets:TF Target HF1H3B | 101 | 5.00E-08 | |
| Up Regulated |
Tftargets:TF Target NFKB | 54 | 4.90E-09 |
| TFactS FOXO3 | 21 | 4.90E-09 | |
| Tftargets:TF Target NFKB1 | 34 | 7.30E-09 | |
| TRRUST:TF Target NFKB1 | 42 | 7.30E-09 | |
| TFactS CTNNB1 | 40 | 4.40E-08 | |
| Tftargets:TF Target FOXJ1 | 22 | 2.00E-07 | |
| Tftargets:TF Target POU3F2 | 35 | 4.00E-07 | |
| TRRUST:TF Target RELA | 38 | 4.20E-07 | |
| Tftargets:TF Target FOXO3 | 28 | 4.80E-07 | |
| TRRUST:TF Target SP1 | 50 | 4.80E-07 | |
| TRRUST:TF Target JUN | 25 | 5.20E-07 | |
| TRRUST:TF Target EGR1 | 19 | 6.10E-07 | |
| Tftargets:TF Target SP1 | 39 | 1.20E-06 | |
| Tftargets:TF Target FOXJ3 | 25 | 1.20E-06 | |
| Tftargets:TF Target FOXL1 | 24 | 1.20E-06 |