Table 1.
Baseline characteristics of selected 2241 pairs with locoregionally advanced nasopharyngeal carcinoma
| Characteristics | CCRT (n = 2241) | IC + CCRT (n = 2241) | P value |
|---|---|---|---|
| No. (%) | No. (%) | ||
| Gender | 0.838a | ||
| Male | 585 (26.1) | 579 (25.8) | |
| Female | 1656 (73.9) | 1662 (74.2) | |
| Age (years) | 0.791b | ||
| Median (range) | 44 (18–77) | 45 (18–76) | |
| Smoking | 0.828a | ||
| Yes | 819 (36.5) | 812 (36.2) | |
| No | 1422 (63.5) | 1429 (63.8) | |
| Drinking | 0.703a | ||
| Yes | 321 (14.3) | 330 (14.7) | |
| No | 1920 (85.7) | 1911 (85.3) | |
| Family History of cancer | 0.606a | ||
| Yes | 572 (25.5) | 557 (24.9) | |
| No | 1669 (74.5) | 1684 (75.1) | |
| T category c | 0.208a | ||
| T1 | 107 (4.8) | 136 (6.0) | |
| T2 | 179 (8.0) | 176 (7.9) | |
| T3 | 1461 (65.2) | 1416 (63.2) | |
| T4 | 494 (22.0) | 513 (22.9) | |
| N category c | 0.03a | ||
| N0 | 186 (8.3) | 188 (8.4) | |
| N1 | 1151 (51.4) | 1138 (50.8) | |
| N2 | 635 (28.3) | 699 (31.2) | |
| N3 | 269 (12.0) | 216 (9.6) | |
| Overall stage c | 0.501a | ||
| III | 1516 (67.6) | 1537 (68.6) | |
| IVA-B | 725 (32.4) | 704 (31.4) | |
| LDH (U/L) | 0.204b | ||
| Median (range) | 174 (67–1009) | 176 (39–753) | |
| EBV-DNA (copies/ml) | 0.141b | ||
| Median (range) | 6345 (0–13,100,000) | 4610 (0–9,080,000) | |
Abbreviations: NPC nasopharyngeal carcinoma, CCRT concurrent chemoradiotherapy, IC induction chemotherapy, LDH lactate dehydrogenase, EBV-DNA Epstein-Barr virus DNA
aP values were calculated by Chi-square test
bP values were calculated by t test
cAccording to the 8th edition of UICC/AJCC staging system