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. 2018 Dec 19;6:152. doi: 10.1186/s40425-018-0474-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Kaplan-Meier analysis of overall survival in ipilimumab treated melanoma patients. Overall survival for patients with biomarker levels in the upper quartile (Q4) vs the lower quartiles (Q1 + Q2 + Q3) for PRO-C3, C1M, C3M and C4M, while for VICM it is the upper quartiles (Q3 + Q4) vs the lower quartiles (Q1 + Q2). A log-rank test was used to determine differences between the survival curves where a p-value of p < 0.05 was considered statistically significant