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. 2018 Dec 19;18:211. doi: 10.1186/s12935-018-0710-0

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Certain interesting three-drug combination results in human glioma cells. Alamar Blue test results after 72-h different three-drug combinations in vitro treatments. The results of the most effective combinations, the significant effects of three drug combinations versus mono-treatments (p < 0.05) were indicated with framed columns, SD was added. Applied drug concentrations: rapamycin—Rapa 50 ng/mL, temozolomide—TMZ 100 µM, doxycycline—Doxy 10 µM; etomoxir—Etom 50 µM; chloroquine—Chl 50 µM in different combinations were the following: rapamycin + temozolomide + doxycycline—Rapa + TMZ + Doxy; rapamycin + doxycycline + chloroquine—Rapa + Doxy + Chl; rapamycin + doxycycline + etomoxir—Rapa + Doxy + Etom; temozolomide + doxycycline + chloroquine—TMZ + Doxy + Chl)