Table 3.

Mixed Model Linear Regression Analysis of the Association of Mean E2 Level During the Trial With CIMT Progression Rate (µm/y): by Time Since Menopause Stratum

Variables	Early Postmenopause (<6 y)	P Value	Late postmenopause (≥10 y)	P Value
Number of participants	N = 248		N = 348
Number of CIMT data points	N = 2435		N = 3173
Intercept	751.0 (734.6, 767.4)	<0.001	792.0 (774.5, 809.5)	<0.001
Time since randomization, y	7.28 (5.43, 9.13)	<0.001	7.67 (6.15, 9.19)	<0.001
Mean E2 level, pg/mL	−0.10 (−0.47, 0.28)	0.62	−0.18 (−0.70, 0.33)	0.49
Time since randomization, y, × mean E2 level, pg/mL	−0.040 (−0.090, -0.001)	0.041	0.063 (0.018, 0.107)	0.006

Numbers in table are β coefficients (95% CI); P value from the Wald test.