Table 4.
Variables | Total Cohort | P Value | HT Group | P Value |
---|---|---|---|---|
Number of participants | N = 596 | N = 297 | ||
Number of data points | N = 5608 | N = 2784 | ||
Intercept | 692.8 (624.1, 761.6) | <0.001 | 706.9 (596.6, 817.1) | <0.001 |
Time since randomization, y | 9.2 (4.9, 13.6) | <0.001 | 7.8 (1.4, 14.2) | 0.017 |
Mean E2 level, pg/mL | −0.28 (−0.77, 0.21) | 0.27 | −0.29 (−0.96, 0.37) | 0.39 |
Time since randomization, y, × mean E2 level, pg/mL | 0.06 (0.02, 0.11) | 0.007 | 0.10 (0.04, 0.17) | 0.002 |
Time since menopause strata | −42.4 (−67.2, -17.6) | <0.001 | −38.7 (−81.9, 4.5) | 0.08 |
Time since randomization, y, × time since menopause strata | −0.39 (−2.75, 1.95) | 0.74 | −0.50 (−4.81, 3.80) | 0.82 |
Mean E2 level, pg/mL, × time since menopause strata | 0.16 (−2.7, 2.0) | 0.62 | 0.10 (−0.73, 0.92) | 0.82 |
Time since randomization, y, × mean E2 level, pg/mL, × time since menopause strata | −0.11 (−0.17, −0.05) | <0.001 | −0.12 (−0.20, -0.04) | 0.004 |
Numbers in table are β coefficients (95% CI); P values from the Wald test. The interaction term of the E2 association with CIMT rate by time since menopause stratum interaction terms represents the early menopause group (using late menopause as the referent group).