Table 4.

Evaluation of the Differential E2 Association With CIMT Progression Rate (µm/y) by Menopause Stratum From Mixed Model Linear Regression Analysis: Total Cohort and Participants in HT Group

Variables	Total Cohort	P Value	HT Group	P Value
Number of participants	N = 596		N = 297
Number of data points	N = 5608		N = 2784
Intercept	692.8 (624.1, 761.6)	<0.001	706.9 (596.6, 817.1)	<0.001
Time since randomization, y	9.2 (4.9, 13.6)	<0.001	7.8 (1.4, 14.2)	0.017
Mean E2 level, pg/mL	−0.28 (−0.77, 0.21)	0.27	−0.29 (−0.96, 0.37)	0.39
Time since randomization, y, × mean E2 level, pg/mL	0.06 (0.02, 0.11)	0.007	0.10 (0.04, 0.17)	0.002
Time since menopause strata	−42.4 (−67.2, -17.6)	<0.001	−38.7 (−81.9, 4.5)	0.08
Time since randomization, y, × time since menopause strata	−0.39 (−2.75, 1.95)	0.74	−0.50 (−4.81, 3.80)	0.82
Mean E2 level, pg/mL, × time since menopause strata	0.16 (−2.7, 2.0)	0.62	0.10 (−0.73, 0.92)	0.82
Time since randomization, y, × mean E2 level, pg/mL, × time since menopause strata	−0.11 (−0.17, −0.05)	<0.001	−0.12 (−0.20, -0.04)	0.004

Numbers in table are β coefficients (95% CI); P values from the Wald test. The interaction term of the E2 association with CIMT rate by time since menopause stratum interaction terms represents the early menopause group (using late menopause as the referent group).