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. 2018 Dec 17;56(1):678–690. doi: 10.1080/13880209.2018.1543332

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — CREA (A) and BUN (B) levels (N = 160). Rats were orally administered different doses of tsothel (66.70, 33.35 and 16.68 mg/kg) daily for 90, 135 and 180 days and subjected to tsothel withdrawal for 30 days. Blood was collected at the termination of each phase of this experiment for analysis by enzyme-linked immunosorbent assay (ELISA). Data represent the mean ± SD. *Significantly different from the control, p < 0.05, **Very significantly different from the control, p < 0.01.