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. 2018 Dec 17;56(1):678–690. doi: 10.1080/13880209.2018.1543332

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Expression of Kim-1 (A), MT-1(B), and GST-Pi (C) mRNA in the kidney (N = 184). Rats were orally administered different doses of tsothel (66.70, 33.35 and 16.68 mg/kg) daily for 90, 135 and 180 days and subjected to tsothel withdrawal for 30 and 120 days, and then total RNA was extracted, purified, and subjected to real-time reverse-transcriptase polymerase chain reaction (RT-PCR) analysis. Data represent the mean ± SD. *Significantly different from the control, p < 0.05, **Very significantly different from the control, p < 0.01.