Table 2. Breast cancer risk by hormonal subtypes according to alcohol consumption at baseline.
| Average daily alcohol intake at baseline (g/day) | ||||||||
|---|---|---|---|---|---|---|---|---|
| N cases/person-years | 0a | 0.1-5 | 5.1-15 | 15.1-30 | >30 | p-value (trend)b | HR (95%CI) per 10g/day | p-valuec |
| All cases | 1,626/605,217 | 4,280/1,488,055 | 3,261/983,711 | 1,475/387,280 | 934/206,177 | 11,576/3,670,440 | ||
| 1.04 (0.98-1.10) | 1.00 (ref) | 1.06 (1.01-1.11) | 1.12 (1.06-1.19) | 1.25 (1.17-1.35) | <.001 | 1.04 (1.03-1.06) | <.001 | |
| ER+/PR+ | 527/598,625 | 1,367/1,470,607 | 970/969,575 | 472/381,199 | 317/202,569 | 3,653/3,622,575 | ||
| 1.06 (0.95-1.18) | 1.00 (ref) | 1.09 (1.00-1.18) | 1.11 (0.99-1.23) | 1.30 (1.15-1.48) | 0.001 | 1.04 (1.01-1.06) | 0.003 | |
| ER+/PR- | 177/596,367 | 404/1,464,086 | 303/965,046 | 162/379,089 | 87/200,949 | 1,133/3,605,537 | ||
| 1.18 (0.98-1.42) | 1.00 (ref) | 1.13 (0.97-1.31) | 1.22 (1.01-1.47) | 1.13 (0.88-1.43) | 0.41 | 1.04 (0.99-1.09) | 0.09 | |
| ER-/PR+ | 27/595,288 | 88/1,461,768 | 53/963,248 | 35/378,194 | 14/200,458 | 217/3,598,956 | ||
| 0.93 (0.59-1.45) | 1.00 (ref) | 1.06 (0.74-1.51) | 1.37 (0.90-2.07) | 1.03 (0.57-1.86) | 0.26 | 1.05 (0.95-1.17) | 0.34 | |
| ER-/PR- | 131/596,019 | 441/1,464,103 | 252/964,537 | 132/378,867 | 94/200,964 | 1,050/3,604,490 | ||
| 0.89 (0.73-1.10) | 1.00 (ref) | 0.92 (0.78-1.08) | 1.03 (0.84-1.26) | 1.28 (1.01-1.61) | 0.06 | 1.05 (1.00-1.10) | 0.03 | |
| HER2- | 246/597,134 | 662/1,466,665 | 457/966,684 | 238/379,950 | 161/201,697 | 1,764/3,612,130 | ||
| 1.11 (0.95-1.29) | 1.00 (ref) | 1.09 (0.96-1.23) | 1.14 (0.98-1.34) | 1.41 (1.17-1.68) | 0.007 | 1.05 (1.02-1.09) | 0.004 | |
| HER2+ | 88/595,882 | 231/1,463,254 | 132/964,054 | 81/378,655 | 38/200,712 | 570/3,602,557 | ||
| 1.14 (0.87-1.49) | 1.00 (ref) | 0.89 (0.72-1.12) | 1.18 (0.90-1.54) | 0.97 (0.68-1.39) | 0.83 | 0.98 (0.92-1.06) | 0.68 | |
| ER-/PR-/HER2- | 25/595,363 | 84/1,461,973 | 62/963,514 | 29/378,261 | 26/200,594 | 226/3,599,705 | ||
| 1.09 (0.68-1.74) | 1.00 (ref) | 1.18 (0.84-1.66) | 1.20 (0.77-1.86) | 1.97 (1.23-3.16) | 0.03 | 1.12 (1.03-1.23) | 0.01 | |
Includes both never and former drinkers
test for a trend in HRs by categories of alcohol intake were computed by assigning consecutive scores (1, 2, 3, 4, 5) to the categories.
test of trend for alcohol intake continuous.
Note: Stratified by center and age at recruitment (1-year interval), and adjusted for menopausal status (pre/peri vs postmenopausal women), oral contraceptive use (yes/no/missing), hormone replacement therapy use (yes/no/missing), height (continuous), weight (continuous), interaction menopause and weight, smoking status (never, ex, current and missing), educational level (primary, no schooling, technical or professional or secondary, longer education, missing), physical activity (inactive, moderately active, moderately inactive, active and unknown), age at first menses (≤ 12, 13-14, 15+, missing), age at first full term pregnancy (nulliparous, ≤21, 22-30, >30, missing), age at menopause (<50, ≥50, missing) and energy intake without alcohol intake.