Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Pharmacogenetic variation of SRD5A2 variants.
| Substitution | Finasteride (Ki nM) |
|---|---|
| WT | 60 (52–72) |
| Single-point variant | |
| P30L (rs61748121) | 420 |
| P48R (rs61748122) | 22 |
| F194L (rs61748126) | 7 |
| R227Q (rs9332964) | 260 |
| F234L (rs9332966) | 200 |
| Compound heterozygotes | |
| V89L–A49T | 150 |
| V89L–T187M | 89 |
| V89L–F234L | 154 |
| Haplotypes (i.e., double mutants) | |
| V89L–A49T | 48 |
| V89L–T187M | 59 |
| V89L–F234L | 94 |
Ki: Inhibition constant; WT: Wild-type.
Reproduced with permission from [23].
