Skip to main content
. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: J Med Chem. 2018 Sep 24;61(19):8847–8858. doi: 10.1021/acs.jmedchem.8b01026

Figure 7.

Figure 7.

Compound 18a is effective in an in vivo mouse model of efficacy. Swiss Webster mice in groups of 2–5 were infected with 103 P. berghei parasites expressing luciferase. From day 2 to day 7, mice were dosed daily with vehicle, 20 mg/kg chloroquine, 20 mg/kg 18a, or 50 mg/kg 18a. Mice were imaged using an IVIS imager at 7 days postinfection (A) and parasitemia was quantified (B). All doses were administered ip.