Table 2.

Growth Inhibition of the Analogues against P. falciparum^a

compd	R1	R2	R3	Pf DXR IC50 [μM]
1a				1.087 ± 0.064
1b				0.511 ± 0.0535
2	Na/H	H	CH3	0.202 ± 0.01535
3	POM	H	CH3	0.018 ± 0.00235
12a	Na/H	H	H	0.019 ± 0.002
12b	Na/H	H	CF3	113.3 ± 22.4
12c	NH4	H	OCH3	28.6 ± 5.0
16d	Na/H	CH(CH3)Ph	CH3	1.2 ± 0.1
16e	Na/H	CH2(4-iprPh)	CH3	1.1 ± 0.0
16f	Na/H	CH2(2-naphthyl)	CH3	26.1 ± 1.1
16g	Na/H	CH2(4-biphenyl)	CH3	2.3 ± 0.4
18a	POM	H	H	0.013 ± 0.002
18b	POM	H	CF3	14.3 ± 2.5
18c	POM	H	OCH3	23.7 ± 6.6
19e	POM	CH2(4-iprPh)	CH3	55.2 ± 1.9
19f	POM	CH2(2-naphthyl)	CH3	50.5 ± 1.1
19g	POM	CH2(4-biphenyl)	CH3	44.1 ± 1.1

^aPf = P. falciparum; IC₅₀ = concentration giving 50% inhibition of Pf growth