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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: J Med Chem. 2018 Sep 24;61(19):8847–8858. doi: 10.1021/acs.jmedchem.8b01026

Table 3.

Computed cLogP, Cytotoxicity, and Selectivity Indexa

graphic file with name nihms-993383-f0004.jpg

compd R cLogP HepG2
IC50
[μM]		 SIPf metabolic
stability MLM
(t1/2) (min)		 plasma
stability
(min)
12a Na/H −5.7 >50 2632 >60 >120
18a POM 0.89 >50 3846 <5 <5
a

cLogP calculated by DataWarrior;44 SIPf = selectivity index for P. falciparum (HepG2 IC50/P. falciparum IC50); MLM = mouse liver microsomes