A. Schematic of the colon-nerve preparation and isolation of the receptive field.
B. - C. Typical recording (B) and quantification (C) of a teased fiber response to stretch (top trace) before (baseline) and after application of inflammatory mediators (IM: histamine, bradykinin, prostaglandin E2, and serotonin, each at 10 μM) or the combination of inflammatory mediators and 10 nM nalfurafine (IM + Nalf). Data represent mean + SEM (One-way RM AVOVA, Holm-Sidak post hoc; * p < 0.05; n = 8 afferents from 8 mice).