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. Author manuscript; available in PMC: 2019 Sep 19.
Published in final edited form as: Neuron. 2018 Sep 19;99(6):1274–1288.e6. doi: 10.1016/j.neuron.2018.08.044

Figure 8. KOR signaling in the periphery inhibits inflammatory mediator-induced sensitization of nociceptive afferents.

Figure 8.

A. Schematic of the colon-nerve preparation and isolation of the receptive field.

B. - C. Typical recording (B) and quantification (C) of a teased fiber response to stretch (top trace) before (baseline) and after application of inflammatory mediators (IM: histamine, bradykinin, prostaglandin E2, and serotonin, each at 10 μM) or the combination of inflammatory mediators and 10 nM nalfurafine (IM + Nalf). Data represent mean + SEM (One-way RM AVOVA, Holm-Sidak post hoc; * p < 0.05; n = 8 afferents from 8 mice).