Table 1.
Satraplatin pharmacokinetic parameters for plasma (A) and cerebrospinal fluid (B)
| Animals | Tmax (h) | Cmax (μM) | AUC0–48h (μM h) | AUC0–inf (μM h) | T½(h) | Cl (l/h/kg) |
|---|---|---|---|---|---|---|
| A: Plasma UF | ||||||
| 1 | 1.1 | 10.6 | 29.3# | 35.1 | 13.4 | 0.34 |
| 2 | 1.0 | 10.4 | 33.2 | 38.2 | 19.5 | 0.31 |
| 3 | 0.5 | 5.7 | 27.4 | 32.1 | 18.8 | 0.37 |
| 4 | 1.0 | 6.9 | 22.6 | 32.1 | 17.4 | 0.37 |
| 5 | 1.0 | 8.3 | 29.2 | 24.7 | 25 | 0.36 |
| Median (range) | 1.0 (0.5–1.1) | 8.3 (5.7–10.6) | 29.2 (22.6–33.2) | 32.1 (24.7–38.2) | 18.8 (13.4–25) | 0.36 (0.31–0.37) |
| Animals | Tmax (h) | Cmax (μM) | AUC0–48h (μM h) | Ratio AUC0–48h CSF: AUC0–48h plasma UF (%) |
|---|---|---|---|---|
| B: CSF | ||||
| 1* | 1.1 | 0.62 | – | – |
| 2 | 1.3 | 0.12 | 2.43 | 7.4 |
| 3 | 2.1 | 0.05 | 1.26 | 4.6 |
| 4 | 1.5 | 0.02 | 0.49 | 2.2 |
| 5 | 1.5 | 0.09 | 1.14 | 3.9 |
| Median (range) | 1.5 (1.1–2.1) | 0.09 (0.02–0.62) | 1.2 (0.49–2.43) | 4.3 (2.2–7.4) |
UF Ultrafiltrate, CSF cerebrospinal Fluid, PK pharmacokinetics, Tmax time of maximum concentration after start of infusion, Cmax maximum concentration, AUC0–48h area under the concentration × time curve from 0 to 48 h, AUC0–inf from 0 to infinity, T1/2 half life, Cl Clearance, CSF: plasma, ratio of AUC 0–48h in CSF to AUC0–48h in plasma
*
Intralumbar catheter
#
AUC0–24h