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. Author manuscript; available in PMC: 2019 Oct 16.
Published in final edited form as: Immunity. 2018 Oct 9;49(4):740–753.e7. doi: 10.1016/j.immuni.2018.08.016

Figure 6. Caspase-11, Hepatocyte-Released HMGB1, and RAGE Are Critical for Pyroptosis and Lethality in Bacterial Sepsis.

Figure 6.

(A–F) Plasma HMGB1, IL-1α, IL-1β, and LTB4 concentrations from mice of indicated genotypes were subjected to either cecum ligation and puncture (CLP) or sham operation.

(G) Cell death in the spleens of indicated transgenic mouse strains was assessed by TUNEL staining. Shown in the right panel is the percentage of TMR-positive cells. Scale bar: 20 μm.

(H–J) Kaplan Meier survival curves for the indicated transgenic mouse strains subjected to CLP.

Circles represent individual mice.*p < 0.05; **p < 0.01; ***p < 0.001; NS: not significant (Student’s t test and log-rank test for survival). See also Figure S4.