Fig 4. Neutralization sensitivity to bNAbs of viral isolates with 4E10-selected aminoacids.

Graphical plot showing the comparison of neutralization sensitivities to several bNAbs of viruses from neutralization HIV-1 database (http://hiv.lanl.gov/catnap) with any of the aminoacid replacements incorporated by LR1-C1 that are indicated in Table 2 (closed grey squares) and with none of the aminoacids incorporated by LR1-C1 (closed grey circles). HIV-1 isolates with Y131, W503 and N643 aminoacids were not included in the analysis because there was no neutralization data or no isolate with this mutation in the database. Mann-Whitney U test was used for comparisons of continuous variables between groups. Simple comparisons were made with the use of a two-sided alpha level of 0.05.