Table 3. Genes displaying >two-fold differences in expression between metastasising and non-metastasising MCTs.
| Gene description (Gene symbol/ID.) | Chromosomal locationb[37] | Fold change (NM/M)d | Adj_p-valuee |
|---|---|---|---|
| TP53 apoptosis effector (PERP) | 1: 30.42 | 2.11 | 0.008 |
| Suprabasin (SBSN) | 1: 117.13c | 2.84 | 0.012 |
| Keratinocyte differentiation-associated protein (KRTDAP) | 1: 117.17c | 7.23 | 0.017 |
| Stratifin (SFN) | 2: 73.27 | 4.71 | 0.012 |
| Plakophilin 1 (PKP1) | 7: 1.92 | 2.45 | 0.003 |
| Keratin 15 (KRT15) | 9: 21.25 | 2.12 | 0.005 |
| Sequence similarity to Keratin-associated protein 4–4 (E-val: 0.0; 470bp; 26%) (KRTAP4-4)a | 9: 21.55 | 2.10 | 0.001 |
| Keratin-associated protein 3–1 (KRTAP3-1) | 9: 21.68 | 2.60 | 0.006 |
| Keratin 10 (KRT10) | 9: 21.86 | 8.50 | 0.014 |
| Early growth response 1 (EGR1) | 11: 26.05 | 2.53 | 0.009 |
| Psoriasis susceptibility 1 candidate 2 (PSORS1C2) | 12: 0.84 | 3.17 | 0.019 |
| Small nucleolar RNA, C/D box 93 (SNORD93) | 14: 36.56 | 0.25 | 0.011 |
| C-type lectin domain family 3, member B (CLEC3B) | 20: 43.32 | 2.57 | 0.007 |
| junB proto-oncogene (JUNB) | 20: 49.36 | 2.25 | 0.018 |
| Epithelial keratin 1 (KRT1) | 27: 2.42 | 7.28 | 0.010 |
| Keratin 5 (KRT5) | 27: 2.57 | 6.81 | 0.013 |
| CD9 antigen (CD9) | 27: 38.74 | 2.07 | 0.002 |
| Sequence similarity to ENSCAFG00000030560 (E-val: 4 x 10−54; 106bp; 60%) (ENSCAFG-30560)a | 31: 38.47 | 2.05 | 0.007 |
| Desmoplakin (DSP) | 35: 7.48 | 2.48 | 0.013 |
aTranscript cluster with no gene annotation. The most significant similarity between the sequence (spliced exons) of the Transcript cluster and a canine mRNA is listed. The significance of the sequence similarity is denoted by the E value and the length of the sequence alignment, and the proportion of the Transcript cluster sequence included in the alignment is stated.
bChromosomal location is denoted by the chromosome name and the gene start base co-ordinate.
cThe genes encoding suprabasin and keratinocyte differentiation-associated protein are adjacent to each on chromosome 1.
dRatio of median gene-level expression values.
ePermutation testing-adjusted t-test p-value