Table 4. Differentially expressed gene-associated enriched functional annotations.

			Gene expression
Functional annotationa	Fold enrichmentb	P-valuec	NM > M	M > NM
GO BP: 0016337 single organismal cell-cell adhesion	6.699	0.005	CDSN, DSP, PKP1, SCRIB
GO BP: 0008285 negative regulation of cell proliferation	3.240	0.006	CD9, ETV3, HDAC4, NF2, SFRP4, SPRY1, STRN, TFAP2A	DNAJA3
GO BP: 0060070 canonical Wnt signaling pathway	6.029	0.008	BCL9L, MYC, PLPP3, SDC1, SFRP4
GO BP: 0051496 positive regulation of stress fiber assembly	7.420	0.014	ARHGEF10, BRAF, EVL, NF2
GO BP: 0008219 cell death	12.058	0.023	AXIN1, EMP2, PMP22
GO BP: 0032060 bleb assembly	10.336	0.031	EMP1, EMP2, PMP22
KP cfa04024: cAMP signaling pathway	2.969	0.045	AFDN, BRAF, CREBBP, FOS	CALM3
KP cfa05210: Colorectal cancer	4.783	0.046	BRAF, FOS, MYC, PIK3R2

^aGO BP: Gene Ontology Biological Process; KP: Kegg Pathway

^bFold enrichment—Proportion of 177 differentially expressed genes with the functional annotation/proportion of ~4,846 genes expressed in the MCTs that have the functional annotation.

^cP-value: Fisher Exact test p-value (EASE score) modified to reduce false positive results.