Table 3. Summary of bivariate associations.
| Patient Characteristics | Muscle Group | |||||||
|---|---|---|---|---|---|---|---|---|
| Discrete Variables | Diaphragm | Biceps | Tibialis | Quadriceps | ||||
| Median (IQR) | p | Median (IQR) | p | Median (IQR) | p | Median (IQR) | p | |
| Sex: Male | -8.1 (-15.9, 15.0) | 0.28 | -1.2 (-9.6, 11.6) | 0.61 | -6.3 (-13.0, 5.5) | 0.31 | -12.5 (-25.6, -8.0) | 0.09 |
| Female | -11.4 (-25.9, 0.0) | -8.8 (-11.5, 14.4) | -3.3 (-7.4, 17.7) | 2.8 (-20.0, 17.0) | ||||
| Age Group: Infant, <1y | -7.1 (-14.8, 2.0) | 0.56 | -9.0 (0.0, 14.4) | 0.03 | 9.24 (-3.5, 20.1) | 0.01 | -0.82 (-12.4, 11.3) | 0.08 |
| Child, >1y | -11.0 (-29.0, 14.3) | -9.6 (-14.6, 4.4) | -8.6 (-13.0, 0.24) | -15.5 (-22.2, -3.90) | ||||
| Race: White | -7.14 (-25.0, 14.3) | 0.86 | -6.6 (-11.5, 11.6) | 0.57 | -7.3 (-12.8, 12.0) | 0.34 | -12.0 (-21.0, 2.9) | 0.44 |
| Black | -11.5 (-31.1, -2.4) | 0.0 (-15.4, 15.0) | -3.2 (-3.5, 1.5) | -8.7 (-22.4, -0.4) | ||||
| Unknown | -2.68 (-20.0, 14.6) | 3.6 (-4.8, 15.8) | -0.2 (-3.1, 52.9) | 21.8 (-22.2, 35.5) | ||||
| Cancer: Yes | -20.0 (-59.3, 51.3) | 0.69 | -2.5 (-10.4, 15.8) | 0.64 | -0.2 (-15.1, 12.0) | 0.50 | -14.3 (-16.7, 21.9) | 0.78 |
| No | -8.12 (-22.4, 6.5 | -4.3 (-11.5, 11.6) | -3.5 (-11.6, 5.5) | -10.4 (-22.2, 3.6) | ||||
| Trisomy 21: Yes | -51.3 (-51.9, -50.6) | 0.25 | -9.6 (-11.5, 0.0) | 0.24 | -10.6 (-13.9, -5.0) | 0.39 | -9.4 (-20.0, 2.8) | 0.04 |
| No | -7.1 (-17.7, 15.0) | 0.6 (-9.6, 11.6) | 2.5 (-7.4, 16.0) | -12.1 (-21.6, 4.6) | ||||
| Hyperglycemia: Yes | -14.8 (-29.0, 0.0) | 0.25 | -9.6 (-11.5, 0.0) | 0.32 | -10.6 (-13.9, -5.0) | 0.05 | -9.4 (-20.0, 2.8) | 0.68 |
| No | -7.1 (-17.1, 15.0) | 0.6 (-9.6, 11.6) | 2.5 (-7.4, 16.0) | -12.1 (-21.6, 4.6) | ||||
| Asthma: Yes | -11.5 (-11.5, -11.5) | 0.84 | 0 (0.0, 0.0) | 0.78 | — | — | -12.9 (-12.9, -12.9) | 0.81 |
| No | -8.1 (-23.7, 10.4) | -4.3 (-11.0, 12.0) | -3.3 (-12.2, 8.7) | -10.4 (-21.0, 3.6) | ||||
| Sepsis: Yes | -20.0 (-22.4, 14.3) | 0.66 | -3.5 (-11.0, 9.7) | 0.50 | -3.5 (-11.6, 45.1) | 0.55 | 6.3 (-35.5, 21.9) | 0.51 |
| No | -8.1 (-21.0, 4.4) | -3.9 (-104, 11.6) | -3.3 (-12.8, 5.5) | -12.1 (-20.9, -0.5) | ||||
| TBI: Yes | -12.1 (-23.1, 4.2) | 0.90 | -14.2 (-45, -3.9) | 0.09 | -15.3 (-19.3,-12.9) | 0.01 | -13.7 (-25.4, -5.2) | 0.56 |
| No | -9.1 (-22.4, 6.5) | -1.2 (-10.4, 12.4) | -2.3 (-8.5, 12.2) | -11.2 (-21.0, 3.7) | ||||
| NMB: None | -15.0 (-22.4, 0) | 0.71 | -9.7 (-14.2, -2.5) | 0.35 | -7.2 (-11.6, 5.5) | 0.86 | -13.2 (-20.0, 2.8) | 0.98 |
| Single | -9.1 (-25.9, 2.3) | 7.4 ((-10.4, 14.4) | -4.2 (-12.8, 17.7) | -10.7 (-30.1, 9.8) | ||||
| Continuous | -7.1 (-11.5, 14.6) | -3.9 (-9.6, 12.4) | -3.2 (-7.4, 1.4) | -8.5 (-22.2, 3.9) | ||||
| Continuous Variables | Correlation Coefficient | p | Correlation Coefficient | p | Correlation Coefficient | p | Correlation Coefficient | p |
| Age (years) | -0.20 | 0.29 | -0.46 | 0.02 | -0.50 | 0.01 | -0.32 | 0.08 |
| BMI (kg/m2) | 0.04 | 0.85 | -0.37 | 0.07 | -0.12 | 0.54 | -0.25 | 0.18 |
| Hospital LOS (days) | -0.09 | 0.63 | 0.31 | 0.13 | -0.34 | 0.07 | -0.09 | 0.60 |
| PICU LOS (days) | 0.05 | 0.81 | 0.19 | 0.38 | -0.07 | 0.73 | -0.14 | 0.48 |
| Duration of intubation (days) | -0.08 | 0.68 | 0.26 | 0.22 | -0.03 | 0.87 | 0.00 | 0.98 |
| PRISM III score | 0.19 | 0.34 | 0.21 | 0.32 | 0.26 | 0.20 | 0.38 | 0.04 |
| SOFA score day 1 | -0.10 | 0.61 | 0.12 | 0.57 | 0.08 | 0.70 | 0.03 | 0.86 |
| SOFA score day 7 | 0.17 | 0.37 | 0.13 | 0.54 | 0.18 | 0.35 | 0.01 | 0.93 |
| Glucose most abnormal in 24 hrs (mg/dL) | -0.23 | 0.24 | -0.11 | 0.62 | -0.30 | 0.13 | -0.03 | 0.87 |
| SaO2 most abnormal (%) | -0.09 | 0.64 | 0.01 | 0.97 | -0.42 | 0.03 | 0.10 | 0.61 |
| Max cumulative steroid dose (mg) | -0.08 | 0.67 | 0.16 | 0.43 | -0.35 | 0.07 | -0.22 | 0.25 |
| Cumulative Hydrocortisone equivalent dose (mg/kg) | 0.00 | 0.98 | 0.23 | 0.27 | -0.22 | 0.25 | -0.12 | 0.50 |