Table 2.
Baseline patient and tumor characteristics of patients with gallbladder cancer from the SEER database according to NLN status
| Characteristics | All patients | <2 | ≥2 | P-value |
|---|---|---|---|---|
| (N=1,754) n (%) | (N=969) n (%) | (N=785) n (%) | ||
| Sex | 0.368 | |||
| Male | 526 (30) | 282 (29.1) | 244 (31.1) | |
| Female | 1,228 (70) | 687 (70.9) | 541 (68.9) | |
| Age | <0.001 | |||
| <60 years | 497 (28.3) | 230 (23.7) | 267 (34.0) | |
| ≥60 years | 1,257 (71.7) | 739 (76.3) | 518 (66.0) | |
| Race | 0.423 | |||
| White | 1,288 (73.4) | 719(74.2) | 569 (72.5) | |
| Black | 243 (12.7) | 119 (12.3) | 104 (13.2) | |
| Othera | 243 (13.9) | 131 (13.5) | 112 (14.3) | |
| Years of diagnosis | 0.001 | |||
| 2004–2007 | 449 (25.6) | 277 (28.6) | 172 (21.9) | |
| 2008–2011 | 550 (31.4) | 307 (31.7) | 243 (31.0) | |
| 2012–2015 | 755 (43) | 385 (39.7) | 370 (47.1) | |
| Histotype | 0.035 | |||
| Adenocarcinoma | 1,279 (72.9) | 712 (73.5) | 567 (72.2) | |
| Squamous cell carcinoma | 21 (1.2) | 7 (0.7) | 14 (1.8) | |
| Adenosquamous carcinoma | 59 (3.4) | 25 (2.6) | 34 (4.3) | |
| Otherb | 395 (22.5) | 225(23.2) | 170 (21.7) | |
| SEER historic stage A | <0.001 | |||
| Localized | 624 (35.6) | 278 (28.7) | 346 (44.1 | |
| Regional | 623 (35.5) | 383 (39.5) | 240 (30.6) | |
| Distant | 507 (28.9 | 308 (31.8) | 199 (25.3) | |
| Grade | <0.001 | |||
| Well/moderate | 963 (54.9) | 480 (49.5) | 483 (61.5) | |
| Poor/anaplastic | 709 (40.4) | 440 (45.4) | 269 (34.3) | |
| Unstage | 82 (4.7) | 49 (5.1) | 33 (4.2) | |
| Tumor size (cm) | 0.821 | |||
| <3 | 768 (43.8) | 420 (43.4) | 348 (44.3) | |
| 3–5 | 604 (34.4) | 348 (35.9) | 256 (32.6) | |
| >5 | 382 (21.8) | 201 (20.7) | 181 (23.1) | |
| TNM stage | <0.001 | |||
| I/II | 366 (20.9) | 154 (15.9) | 212 (27.0) | |
| III/IV | 685 (39.0) | 391 (40.4) | 294 (37.5) | |
| Unstage | 703 (40.1) | 424 (43.7) | 279 (35.5) | |
| No. of TLNs dissected (median) | 2.0 | 1.0 | 5.0 | <0.001 |
| No. of PLNs dissected (median) | 1.0 | 1.0 | 0.0 | <0.001 |
| No. of NLNs dissected (median) | 1.0 | 0.0 | 4.0 | <0.001 |
Notes:
a
Other includes American Indian/Alaskan native, Asian/Pacific Islander, and unknown.
b
Other cancers includes signet ring, small cell, giant and spindle cell, non-small cell, carcinoma not otherwise specified, undifferentiated, mucinous adenocarcinoma, papillary adenocarcinoma, and carcinoma, duct, adenocarcinoma with metaplasia, cholangiocarcinoma, neoplasm, and malignant. Data shown as number of patients (%), or median, as indicated.
Abbreviations: NLNs, negative lymph nodes; PLNs, positive lymph nodes; SEER, Surveillance, Epidemiology, and End Results; TLNs, total regional lymph nodes.