Table 2. The 14 genome-wide significant variants associated with PCOS in the meta-analysis.

Chr:Position1	rsID	Alleles2	EAF3	Beta	Odds Ratio (95% CI)4	Std. Error	Nearest Gene	P-value	Effective N5	Ref6
2:43561780	rs7563201	A/[G]	0.4507	-0.1081	0.90 (0.87–0.93)	0.0172	THADA	3.678e-10	17192
2:213391766	rs2178575	G/[A]	0.1512	0.1663	1.18 (1.13–1.23)	0.0219	ERBB4	3.344e-14	17192	17
5:131813204	rs13164856	[T]/C	0.7291	0.1235	1.13 (1.09–1.18)	0.0193	IRF1/RAD50	1.453e-10	17192	17
8:11623889	rs804279	A/[T]	0.2616	0.1276	1.14 (1.10–1.18)	0.0184	GATA4/NEIL2	3.761e-12	16895	16
9:5440589	rs10739076	C/[A]	0.3078	0.1097	1.12 (1.07–1.16)	0.0197	PLGRKT	2.510e-08	17192
9:97723266	rs7864171	G/[A]	0.4284	-0.0933	0.91 (0.88–0.94)	0.0168	FANCC	2.946e-08	17192	16
9:126619233	rs9696009	G/[A]	0.0679	0.202	1.22 (1.15–1.30)	0.0311	DENND1A	7.958e-11	17192
11:30226356	rs11031005	[T]/C	0.8537	-0.1593	0.85 (0.82–0.89)	0.0223	ARL14EP/FSHB	8.664e-13	17192	16,17
11:102043240	rs11225154	G/[A]	0.0941	0.1787	1.20 (1.13–1.26)	0.0272	YAP1	5.438e-11	17192	17
11:113949232	rs1784692	[A]/G	0.8237	0.1438	1.15 (1.10–1.14)	0.0226	ZBTB16	1.876e-10	17192
12:56477694	rs2271194	A/[T]	0.416	0.0971	1.10 (1.07–1.14)	0.0166	ERBB3/RAB5B	4.568e-09	17192	17
12:75941042	rs1795379	C/[T]	0.2398	-0.1174	0.89 (0.86–0.92	0.0195	KRR1	1.808e-09	17192	17
16:52375777	rs8043701	[A]/T	0.815	-0.1273	0.88 (0.85–0.92)	0.0208	TOX3	9.610e-10	17192
20:31420757	rs853854	A/[T]	.4989	-.0975	0.91 (0.88–0.94)	0.0163	MAPRE1	2.358e-09	17192

¹Chr—Chromosome:Position (bp) in hg19;

²Alleles are shown as Major/Minor by allele frequency in 1000G EUR cohort, with the effect allele shown within [];

³Effect allele frequency;

⁴95% Confidence Interval of the Odds Ratio;

⁵Effective N—effective sample size;

⁶Ref = Reference.

Loci previously identified in GWAS studies of European ancestry are referenced. Novel associations with PCOS not previously reported are shown in bold. EAF = Effect Allele Frequency.