Table 3. Association of PCOS GWAS meta-analysis susceptibility variants and PCOS related traits.
| Chr:Position | rsID | Gene | Ref. allele | Other allele | Hyperandrogenism | PCOM | OD | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| EAF | Beta | P-value | Beta | P-value | Beta | P-value | |||||
| 2:213391766 | rs2178575 | ERBB4* | G | A | 0.83 | -0.126 | 4.3E-03 | -0.24 | 1.4E-05 | -0.23 | 1.2E-11 |
| 2:43561780 | rs7563201 | THADA*† | G | A | 0.56 | 0.061 | 8.0E-02 | 0.16 | 3.7E-04 | 0.08 | 1.5E-03 |
| 5:131813204 | rs13164856 | IRF1/RAD50* | T | C | 0.73 | 0.092 | 1.8E-02 | 0.16 | 1.4E-03 | 0.08 | 5.6E-03 |
| 8:11623889 | rs804279 | GATA4/NEIL2* | A | T | 0.27 | 0.126 | 8.7E-04 | 0.22 | 1.5E-06 | 0.16 | 9.9E-09 |
| 9:126619233 | rs9696009 | DENND1A† | G | A | 0.94 | -0.330 | 2.9E-07 | -0.32 | 4.0E-05 | -0.36 | 4.4E-15 |
| 9:5440589 | rs10739076 | PLGRKT | A | C | 0.30 | 0.026 | 5.3E-01 | 0.10 | 5.9E-02 | 0.00 | 8.9E-01 |
| 9:97723266 | rs7864171 | C9orf3*† | G | A | 0.60 | 0.124 | 3.8E-04 | 0.19 | 1.3E-05 | 0.10 | 2.3E-04 |
| 11:30226356 | rs11031005 | ARL14EP/FSHB* | T | C | 0.85 | -0.079 | 8.2E-02 | -0.18 | 1.3E-03 | -0.13 | 2.8E-04 |
| 11:102043240 | rs11225154 | YAP1*† | G | A | 0.91 | -0.144 | 1.4E-02 | -0.24 | 3.5E-04 | -0.23 | 5.7E-08 |
| 11:113949232 | rs1784692 | ZBTB16 | T | C | 0.85 | 0.146 | 4.6E-03 | 0.30 | 2.8E-06 | 0.21 | 6.6E-09 |
| 12:75941042 | rs1795379 | KRR1* | T | C | 0.24 | -0.104 | 8.0E-02 | -0.16 | 1.5E-03 | -0.11 | 1.8E-04 |
| 12:56477694 | rs2271194 | ERBB3/RAB5B† | A | T | 0.42 | 0.126 | 2.7E-04 | 0.17 | 7.9E-05 | 0.13 | 1.4E-06 |
| 16:52375777 | rs8043701 | TOX3† | A | T | 0.82 | -0.166 | 1.4E-04 | -0.17 | 1.5E-03 | -0.08 | 9.2E-03 |
| 20:31420757 | rs853854 | MAPRE1 | T | A | 0.50 | 0.111 | 9.8E-04 | 0.10 | 2.1E-02 | 0.05 | 3.8E-02 |
Significant associations are highlighted in bold. Variant previously reported as a PCOS risk variant in
*European or
†Han Chinese populations.