Table 1.
Summary statistics for the full cohort, therapeutic range dataset, early dataset, and steady state dataset1
| Covariate | Full Cohort (n = 544 patients with 961 samples) |
Therapeutic Range Dataset (n = 303 patients with 409 samples) |
Early Dataset (n = 120 patients with 159 samples) |
Steady State Dataset (n = 244 patients with 322 samples) |
||||
|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Complete Data, n (%) | Mean (SD) | Complete Data, n (%) | Mean (SD) | Complete Data, n (%) | Mean (SD) | Complete Data, n (%) | |
| Baseline PASI | 13.5 (6.7) | 495 (91.0) | 15.9 (5.6) | 303 (100.0) | 16.2 (6.4) | 120 (100.0) | 15.9 (5.6) | 244 (100.0) |
| Height (cm) | 172.3 (10.3) | 520 (95.6) | 172.0 (10.1) | 295 (97.4) | 172.4 (9.3) | 114 (95.0) | 172.3 (10.3) | 239 (98.0) |
| Weight (kg) | 90.9 (20.4) | 471 (86.6) | 92.3 (20.7) | 277 (91.4) | 92.3 (22.2) | 106 (88.3) | 92.9 (21.1) | 223 (91.4) |
| Waist (cm) | 102.1 (15.6) | 443 (81.4) | 103.0 (16.0) | 266 (87.8) | 103.2 (16.9) | 103 (85.8) | 103.8 (15.7) | 214 (87.7) |
| BMI (kg/m2) | 30.8 (6.7) | 465 (85.5) | 31.3 (7.2) | 274 (90.4) | 31.2 (7.3) | 106 (88.3) | 31.3 (7.0) | 221 (90.6) |
| Age (years) | 44.3 (12.2) | 544 (100.0) | 44.0 (12.3) | 303 (100.0) | 43.8 (12.4) | 120 (100.0) | 44.1 (12.2) | 244 (100.0) |
| Disease duration (years) | 22.0 (12.0) | 498 (91.5) | 21.5 (12.4) | 282 (93.1) | 20.8 (11.5) | 104 (86.7) | 21.1 (11.8) | 233 (95.5) |
| n (%) | n (%) | n (%) | n (%) | |||||
| Ethnicity, white | 484 (89.0) | 544 (100.0) | 272 (89.8) | 303 (100.0) | 103 (85.8) | 120 (100.0) | 216 (88.5) | 244 (100.0) |
| Sex, male | 338 (62.1) | 544 (100.0) | 191 (63.0) | 303 (100.0) | 80 (66.7) | 120 (100.0) | 161 (66.0) | 244 (100.0) |
| Inflammatory arthritis | 109 (23.5) | 464 (85.3) | 62 (22.6) | 274 (90.4) | 27 (26.2) | 103 (85.8) | 54 (24.1) | 224 (91.8) |
| Ever smoked | 298 (56.7) | 526 (96.7) | 172 (57.9) | 297 (98.0) | 66 (57.9) | 114 (95.0) | 141 (58.5) | 241 (98.8) |
| Palm psoriasis | 87 (16.9) | 515 (94.7) | 46 (16.0) | 288 (95.0) | 21 (19.4) | 108 (90.0) | 38 (16.4) | 232 (95.1) |
| Biologic naive | 375 (68.9) | 544 (100.0) | 237 (78.2) | 303 (100.0) | 97 (80.8) | 120 (100.0) | 189 (77.5) | 244 (100.0) |
Abbreviations: BMI, body mass index; PASI, Psoriasis Area and Severity Index; SD, Standard Deviation.
1
Summaries for the therapeutic range, early, and steady state datasets are restricted to patients with baseline PASI > 10. Height, waist, and body mass index measurements provided for information only; weight used in modeling.