Table 1.
Baseline Demographic and Clinical Factors by Study
| Demographics/Clinical Factors | PPCOS II n = 607 | AMIGOS n = 647 |
|---|---|---|
| Age, mean ± SD | 28.8 ± 4.21 | 32.3 ± 4.19 |
| Race | ||
| White | 81 (486) | 84 (517) |
| Black | 13 (80) | 7 (45) |
| Other | 5.4 (32) | 8 (51) |
| Ethnicity | ||
| Non-Hispanic | 80 (479) | 88 (539) |
| Hispanic | 20 (119) | 12 (74) |
| BMI, mean ± SD, kg/m2 | 35.5 ± 9.21 | 27.1 ± 6.64 |
| Pretreatment vitamin D status | ||
| 25(OH)D, mean ± SD, ng/dL | 22.3 ± 7.6 | 25.4 ± 8.7 |
| <20 (deficient), ng/mL | 41 (246) | 25 (155) |
| 20–29.9 (insufficient), ng/mL | 45 (270) | 49 (303) |
| ≥30 (sufficient), ng/mL | 14 (82) | 25 (155) |
| Gravidity (Y/N) | 34 (202) | 41 (249) |
| Smoking (Y/N) | 15 (90) | 8 (47) |
| SHBG, mean ± SD, nmol/L | 33.2 ±,22.8 | 59.6 ± 28.4 |
| Free androgen index, mean ± SDa | 64.5 ± 47.7 | 18.1 ± 54.1 |
| Total testosterone, mean ± SD, ng/dL | 54.6 ± 28.0 | 25.1 ± 16.0 |
| HOMA IR, mean ± SDb | 4.43 ± 9.79 | 2.11 ± 3.76 |
| HOMA IR categories of insulin resistance, % (N) | ||
| Normal | 50 (297) | 84 (515) |
| Moderate | 22 (130) | 9 (56) |
| Severe | 29 (171) | 7 (42) |
| AMH, mean ± SD, ng/mL | 8.08 ± 7.19 | 2.61 ± 2.09 |
To convert to SI units for 25(OH)D, multiply by 2.5; for total testosterone, multiply by 0.0347; for AMH, multiply by 7.14.
Abbreviations: HOMA IR, Homeostatic Model Assessment of Insulin Resistance; N, no; SHBG, sex hormone binding globulin; Y, yes.
a
Free androgen index: total testosterone (nmol/L)/SHBG × 100.
b
HOMA IR: fasting insulin × tasting glucose/405; HOMA-IR cutpoints for insulin resistance: normal, <3; moderate, 3–5; severe, >5.