Table 1. Contraindication to oral anticoagulation. Part A: contraindication to warfarin; part B: contraindication to new oral anticoagulation^7,8).

Contraindication to Warfarin therapy, part (A)	Contraindication to new oral anticoagulation therapy, part (B)
Patients with history of hypersensitivity to the drug	Patients with known history of hypersensitivity to the drugs
Patient with history of threatened abortion, eclampsia, and preeclampsia. Unsupervised or independently patients with senility or high fall risk	Patients with history of active significant bleeding, disorder of hemostasis, for example, von Willebrand disease or coagulation factor deficiency, prosthetic heart valve, liver disease with an alanine transaminase (ALT) > 2 times upper limit of normal
Pregnant women except in those pregnant women with mechanical heart valves	Patients with concomitant medication known to affect pharmacokinetics, for example, concomitant warfarin therapy
Patients with history of pathologic condition of the blood (blood dyscrasias)	Patients with history of pregnancy or breast feeding
Patients with history of hemorrhagic tendencies, for example, active peptic ulcers or patients with history of obvious bleeding of the gastrointestinal, genitourinary, or respiratory tract, central nervous system hemorrhage, cerebral aneurisms, dissecting aorta, pericarditis, pericardial effusions, or bacterial endocarditis	Patients with history of poor renal function, for example, dabigatran is contraindicated in severe renal impairment creatinine clearance (CrCL) <30 mL/min, edoxaban is contraindicated in patients with CrCL >95 mL/min, rivaroxaban and apixaban are contraindicated in patients with CrCL <15 mL/min