Fig. 1. Schematic summary of the regulation of liver type glucose transporter (glucose transporter type 2 [GLUT2]) and glucokinase (Gck) promoter. During the long journey to understand glucose homeostasis, main interest of my group was how glucose sensors, GLUT2 and glucokinase, are regulated by transcription factors. Tissue-specific study, and disease-specific alteration as well, revealed that many transcriptional factors are interconnected in the regulation of glucose sensor in liver. C/EBP, CCAAT/enhancer binding protein; PPARγ, peroxisome proliferator-activated receptor γ; RXRα, retinoid X receptor α; PPRE, PPARγ response element; SREBP-1c, sterol regulatory element binding protein-1c; SRE, sterol regulatory element; HNF1α, hepatocyte nuclear factor 1 α; HNF, hepatocyte nuclear factor; FOXA2, forkhead box A2; LXRα, liver X-receptor α; SHP, small heterodimer partner; L-GcK, liver glucokinase; TFE3, transcription factor E3; LXRE, liver X-receptor response element.