Fig. 2. Role of cyclic AMP-responsive element-binding protein 3 (CREB3)-like 4 (CREB3L4) on the adipogenesis. (A) In preadipocytes, CREB3L4 acts as a negative regulator of adipogenesis by both regulating the stability of CCAAT/enhancer binding protein β (C/EBPβ) protein and increasing GATA binding protein 3 (GATA3) expression. (B) Proposed mechanism of action of CREB3L4 in prostate cancer progression. Adapted from Kim et al. [24,26]. IBMX, 3-isobutyl-1-methylxanthine; AR, androgen receptor; IRE1α, inositol requiring enzyme 1α.
