Table 1.

Difference values (as a percentage) between various methods with sub-complete data when compared to the full data set analysis (gold standard method); method 1: t_1/2 average applied to 4 h data; method 2: t_1/2 average applied to 24 h data; method 3: t_1/2 patient from cycle 1 applied to 4 h data on subsequent cycles; method 4: t_1/2 patient from cycle 1 applied to 24 h data on subsequent cycles; method 5: cycle 1 %IA at 120 h applied to subsequent cycles with only 4 h and 24 h data acquired

Method	N	Average difference (%)	Standard deviation (%)	Maximum difference (%)	Median difference (%)
1	40	59	69	275	26
2	40	30	19	80	27
3	60	13	34	132	8
4	60	2	16	45	1
5	60	14	16	89	10

N the number of cycles analysed to derive difference values