Table 6.
Hazard ratios of hospitalization for infections in a cohort of 6801 Italian patients with rheumatoid arthritis, psoriasis, or ankylosing spondylitis, by underlying disease.
| Rheumatoid arthritis (N = 3856) |
Psoriatic arthritis or severe psoriasis (N = 2139) |
Ankylosing spondylitis (N = 806) |
||||
|---|---|---|---|---|---|---|
| Hazard ratio (95% confidence interval)a |
P | Hazard ratio (95% confidence interval)a |
P | Hazard ratio (95% confidence interval)a |
P | |
| Sex | ||||||
| Female | 0.91 (0.67–1.25) | 0.5781 | 1.45 (0.88–2.40) | 0.1444 | 1.14 (0.48–2.72) | 0.7713 |
| Male | 1.00 (–) | 1.00 (–) | 1.00 (–) | |||
| Age category | ||||||
| <40 | 1.00 (–) | 1.00 (–) | 1.00 (–) | |||
| 40–64 | 1.28 (0.69–2.39) | 0.4371 | 1.09 (0.53–2.27) | 0.9132 | 1.19 (0.44–3.18) | 0.7291 |
| ≥65 | 5.07 (2.78–9.25) | <0.0001 | 1.92 (0.81–4.56) | 0.1397 | 3.09 (0.84–11.41) | 0.0904 |
| First exemption before 2011 | ||||||
| No | 1.00 (–) | 1.00 (–) | 1.00 (–) | |||
| Yes | 0.94 (0.66–1.32) | 0.7116 | 0.82 (0.46–1.47) | 0.5048 | 0.47 (0.191.17) | 0.1048 |
| Cumulative steroid use > 180 days | ||||||
| No | 1.00 (–) | 1.00 (–) | 1.00 (–) | |||
| Yes | 1.31 (0.95–1.80) | 0.0964 | 1.39 (0.63–2.95) | 0.3980 | 2.01 (0.58–7.00) | 0.2742 |
| Charlson’s Comorbidity Index (continuous) | 1.31 (1.15–1.49) | <0.0001 | 2.07 (1.44–2.98) | <0.0001 | n/a | |
| Annual number of traditional DMARD prescriptions | 1.07 (1.03–1.12) | 0.0008 | 1.11 (1.02–1.20) | 0.0129 | 1.14 (1.08–1.27) | 0.0115 |
| Time to first biological drug prescription | 1.49 (1.01–2.21) | 0.0446 | 1.11 (0.56–2.21) | 0.7575 | 2.91 (1.28–6.62) | 0.0111 |
a
Adjusted for all of the variables listed in the table.