Table 1.
Baseline characteristics of pAIH patients and controls.
| Characteristics | pAIH n = 56 (%) | Controls n = 44 (%) | P value |
|---|---|---|---|
| Demographic data | |||
| Female | 41 (73.21) | 30 (68.18) | 0.659 |
| Male | 15 (26.79) | 14 (31.82) | |
| Age, years, mean ± SD | 8.36 ± 3.44 | 8.93 ± 2.6 | 0.1 |
| Laboratory investigations | |||
| AST, (IU/L), mean ± SD | 600.36 ± 424.44 | 19.14 ± 7.26 | <0.0001* |
| ALT, (IU/L), mean ± SD | 543.71 ± 382.01 | 16.66 ± 7.22 | <0.0001* |
| Total bilirubin, (mg/dL), mean ± SD | 4.92 ± 3.71 | 0.39 ± 0.23 | <0.0001* |
| Albumin, (g/dL), mean ± SD | 3.32 ± 0.68 | 4.511 ± 0.5 | <0.0001* |
| INR, mean ± SD | 1.78 ± 0.67 | 1.03 ± 0.085 | <0.0001* |
| IgG, (mg/dL), mean ± SD | 3019 ± 1353 | 958.8 ± 139.8 | <0.0001* |
| ANA ≥ 1:40, n (%) | 40 (71.43) | 0 (0) | <0.0001* |
| SMA ≥ 1:40, n (%) | 52 (92.86) | 0 (0) | <0.0001* |
| Anti-LKM ≥ 1:40, n (%) | 5 (8.93) | 0 (0) | 0.065 |
| Clinical data | |||
| Cirrhosis, n (%) | 23 (41.07) | – | – |
| Hypersplenism, n (%) | 10 (17.86) | – | – |
Values are expressed as the mean ± standard deviation (SD) or number n (%). pAIH, paediatric-onset autoimmune hepatitis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; INR, international normalized ratio; IgG, immunoglobulin G; ANA, antinuclear antibodies; SMA, smooth muscle antibodies; anti-LKM, antibodies against liver kidney microsomes. Categorical data were analysed using Fisher’s exact test. Continuous data were analysed using an unpaired Student’s t-test or the Mann Whitney test after testing for normality.
*
Indicates statistical significance (P < 0.05).