Table 4.
Haplotype and joint analysis of rs6000782 (A/C) and rs1799724 (C/T) polymorphisms in pAIH patients compared to controls.
| pAIH, n (%) | Controls, n (%) | P | OR (CI) | |
|---|---|---|---|---|
| Combined genotypes | ||||
| AA + CC | 19 (33.93) | 27 (61.36) | Ref | |
| AA + CT | 11 (19.64) | 5 (11.36) | 0.083 | 3.13 (0.93–10.5) |
| AA + TT | 1 (1.79) | 0 (0) | 0.426 | – |
| AC + CC | 12 (21.43) | 8 (18.18) | 0.189 | 2.1 (0.73–6.2) |
| AC + CT | 6 (10.71) | 4 (9.09) | 0.315 | 2.1 (0.53–8.6) |
| AC + TT | 1 (1.79) | 0 (0) | 0.426 | – |
| CC + CC | 0 (0) | 0 (0) | – | – |
| CC + CT | 5 (8.93) | 0 (0) | 0.018* | – |
| CC + TT | 1 (1.79) | 0 (0) | 0.426 | – |
| Combined alleles | ||||
| AC | 128 (57.14) | 138 (78.41) | Ref | |
| AT | 34 (15.18) | 14 (7.96) | 0.005* | 2.62 (1.34–5.1) |
| CC | 40 (17.86) | 20 (11.36) | 0.010* | 2.16 (1.20–3.88) |
| CT | 22 (9.82) | 4 (2.27) | <0.001* | 5.93 (1.99–17.7) |
Values are expressed in numbers. Ref, reference. pAIH, n = 56, healthy controls, n = 44.
*
Indicates statistical significance (P < 0.05).