Table 5.
Association of rs6000782 and rs1799724 genotypes with characteristics of pAIH patients.
| Parameter | rs6000782 |
rs1799724 |
||||||
|---|---|---|---|---|---|---|---|---|
| (n=) | AA (31) |
AC (19) |
P | CC (6) |
P | CC (31) |
CT + TT (25) |
P |
| Sex (F/M) | 23/8 | 12/7 | 0.53 | 6/0 | 0.31 | 22/9 | 19/6 | 0.77 |
| Age (years) | 8.1 ± 3.1 | 9.3 ± 4.2 | 0.25 | 6.8 ± 1.1 | 0.31 | 8.9 ± 3.8 | 7.7 ± 2.9 | 0.22 |
| AST (IU/L) | 550 ± 414 | 561 ± 381 | 0.73 | 986 ± 478 | 0.09 | 582 ± 453 | 622 ± 394 | 0.73 |
| ALT (IU/L) | 454 ± 276 | 525 ± 382 | 0.56 | 1,066 ± 497 | 0.02* | 498 ± 343 | 601 ± 426 | 0.58 |
| T. bilirubin (mg/dL) | 4.5 ± 3.2 | 4.5 ± 3.6 | 0.96 | 8.1 ± 5.5 | 0.09 | 4.9 ± 3.7 | 5 ± 3.8 | 0.75 |
| Albumin (g/dL) | 3.3 ± 0.7 | 3.5 ± 0.6 | 0.21 | 2.8 ± 0.8 | 0.16 | 3.4 ± 0.6 | 3.2 ± 0.8 | 0.15 |
| INR | 1.6 ± 0.5 | 1.8 ± 0.7 | 0.43 | 2.5 ± 0.9 | 0.01* | 1.7 ± 0.6 | 1.9 ± 0.7 | 0.15 |
| IgG (mg/dL) | 2,894 ± 1,226 | 2,788 ± 1,109 | 0.57 | 4,399 ± 2,028 | 0.03* | 2,795 ± 1,298 | 3,298 ± 1,394 | 0.06 |
| ANA ≥ 1:40, n | 22 | 13 | 1 | 5 | 1 | 26 | 14 | 0.05 |
| SMA ≥ 1:40, n | 30 | 16 | 0.15 | 6 | 1 | 30 | 22 | 0.31 |
| Anti-LKM ≥ 1:40, n | 4 | 1 | 0.64 | 0 | 1 | 3 | 2 | 1 |
| Cirrhosis, n | 12 | 7 | 1 | 4 | 0.37 | 11 | 12 | 0.42 |
Values are expressed as the mean ± standard deviation (SD) or number n (%). pAIH, paediatric-onset autoimmune hepatitis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; INR, international normalized ratio; IgG, immunoglobulin G; ANA, antinuclear antibodies; SMA, smooth muscle antibodies; anti-LKM, antibodies against liver kidney microsomes. Categorical data were analysed using Fisher’s exact test. Continuous data were analysed using an unpaired Student’s t-test or the Mann Whitney test after testing for normality.
*
Indicates statistical significance (P < 0.05).