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Inhibition of NCX attenuates airway hyperresponsiveness in a murine model of allergic airway inflammation. C57BL/6 mice were immunized and challenged with PBS (control) or ovalbumin in a 21-day model. Thirty min before a methacholine dose-response curve mice received KB-R7943 (10 mg/kg, intraperitoneally) or vehicle. ∗∗P < 0.001 vs. control, n = 12. No statistical differences at all doses between control and KB-R7943-treated ovalbumin mice, n = 4.
