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. 2018 Dec 13;8:591. doi: 10.3389/fonc.2018.00591

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Copyright © 2018 Hussain, Lee, Abba, Chen and Aldaz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic Pathways significantly associated with WWOX protein interactome. (A) Bar graph represents biological pathways that are significantly over-represented within the list of 216 WWOX interactors. See Supplementary File 4 for detail of interactors and p-values of pathway shown (B) Among the most significantly associated pathways we identified key metabolic pathways including: “Valine, Leucine, and Isoleucine degradation” (KEGG pathway hsa00280), “Glycolysis/Gluconeogenesis” (KEGG pathway hsa00010), “Pyruvate metabolism” (KEGG pathway hsa00620), and “Fatty acid degradation” (KEGG pathway hsa00071). All pathways converge to Acetyl-CoA generation the key molecule that delivers its acetyl group for oxidation and energy production to the tricarboxylic acid (TCA) cycle. WWOX interactors identified in our TAP-MS dataset are highlighted in red.