Table 1.
Basic characteristics of the included articles in the meta-analysis.
| Author name | Publication year | Study population | miRNAs | Cancer | Samples size | Outcome | Citations |
|---|---|---|---|---|---|---|---|
| Bri 'd M. Ryan | 2012 | American | mir-608(rs4919510) | CRC | 245 | OS | (63) |
| Brock C. Christensen | 2010 | American | mir-196a-2 (rs11614913) | HNSCC | 323 | OS | (27) |
| Chang Zheng | 2017 | Chinese | miR-219-1(rs107822, rs213210) | NSCLC | 405 | OS | (31) |
| Chengyuan Wang | 2016 | Chinese | mir-146a(rs2910164); mir-149(rs2292832); mir-196a2(rs11614913); mir-499(rs3746444) |
SCCNOP | 996 | OS; DFS | (39) |
| Chung-Ji Liu | 2013 | Chinese | miR-196a2(rs11614913) | OSCC | 315 | OS | (9) |
| Dae Ho Ahn | 2013 | Korean | mir-146a(rs2910164); mir-149(rs2292832); mir-196a2(rs11614913); mir-499(rs3746444) |
GC | 160 | OS | (45) |
| Fuzhen Qi | 2014 | Chinese | miR-106b-25(rs999885) | HCC | 331 | OS | (40) |
| Guopeng Yu | 2016 | Chinese | miR-492(rs2289030) | HCC | 362 | OS | (50) |
| Jeannette T. Bensen | 2013 | American | miR-16-1/15a(rs9535416); miR-206(rs6920648); miR-34b/c(rs4938723) |
Breast cancer | 1,946 | OS | (30) |
| Jiali Xu | 2013 | Chinese | miR-27a(rs895819) | NSCLC | 576 | OS | (53) |
| Jiaze An | 2014 | Chinese | miR-378(rs1076064) | HCC | 331 | OS | (60) |
| Jing Jiang | 2016 | Chinese | miR-146a(rs2910164) | GC | 838 | OS | (12) |
| Jinliang Xing | 2012 | Chinese | miR-146a(rs2910164); miR-27a(rs895819); mir-423 (rs6505162); miR-492(rs2289030); miR-604(rs2368392); miR-605(rs2043556); miR-608 (rs4919510) |
CRC | 408 | OS; RFS | (65) |
| Ji-Yong Ma | 2015 | Chinese | miR-27a(rs895819) | NSCLC | 542 | OS; RFS | (25) |
| Juan Li | 2016 | Chinese | miR-196a2(rs11614913) | HCC | 109 | OS | (49) |
| Kaipeng Xie | 2013 | Chinese | let-7 (rs10877887) | HCC | 331 | OS | (33) |
| Kaipeng Xie | 2015 | Chinese | miR-155(rs767649) | NSCLC | 1,001 | OS | (32) |
| Kyong-Ah Yoon | 2012 | Korean | mir-146a (rs2910164); miR-196a2(rs11614913); miR-219-1(rs213210); miR-26a-1(rs7372209); miR-27a(rs895819); miR-423 (rs6505162); miR-492(rs2289030) |
NSCLC | 388 | RFS | (62) |
| Kyung Min Shin | 2016 | Korean | let-7a-1(rs10739971; rs1143770); let-7a-2(rs629367); let-7f-2(rs17276588) |
NSCLC | 761 | OS; RFS | (58) |
| Lianghe Jiao | 2014 | Chinese | miR-125a(rs12976445); miR-218(rs11134527); miR-423(rs6505162); miR-608(s4919510) |
Breast cancer | 196 | OS | (41) |
| Lin Jiang | 2014 | Chinese | miR-218(rs11134527) | ESCC | 706 | OS | (59) |
| Meenakshi Umar | 2013 | India | miR-146a(rs2910164);miR-196a2(rs11614913); miR-423(rs6505162); miR-499(rs3746444) |
ESCC | 153 | OS | (56) |
| Meilin Wang | 2012 | Chinese | miR-146a(rs2910164) | Bladder cancer | 74 | RFS | (44) |
| Mi Jeong Hong | 2013 | Korean | mir-146a(rs2910164); miR-149(rs2292832); miR-196a2(rs11614913); miR-499(rs3746444) |
NSCLC | 363 | OS; DFS | (55) |
| Moon JU Jang | 2011 | Korean | mir-146a(rs2910164); miR-149(rs2292832); miR-196a2(rs11614913); miR-499(rs3746444) |
CRC | 407 | OS; RFS | (10) |
| Mulong Du | 2014 | Chinese | miR-196a(rs11614913) | RCC | 311 | OS | (48) |
| Myung Su Son | 2013 | Korean | miR-34 (rs4938723) | HCC | 157 | OS | (68) |
| Ning Zhan | 2013 | Chinese | miR-27a(rs895819) | Breast cancer | 62 | OS; RFS | (4) |
| Olusola O. Faluyi | 2017 | Canada | miR-124-1 (rs531564) | esophageal adenocarcinoma | 369 | OS | (37) |
| Pei-Wen Yang | 2014 | Chinese | mir-196a2(rs11614913); miR-26a-1(rs7372209); miR-30c-1(rs16827546); miR-423 (rs6505162); miR-608 (rs4919510) |
ESCC | 129 | OS; RFS | (64) |
| Qian Xu | 2014 | Chinese | let-7a-2(rs629367) | GC | 150 | OS | (57) |
| Shizhi Wang | 2013 | Chinese | miR-196a2(rs11614913) | GC | 940 | OS | (11) |
| Shuangshuang Wu | 2015 | Chinese | miR-124-2(rs298206); miR-184(rs919968); miR-218-1(rs3775815) |
NSCLC | 1,001 | OS | (36) |
| Soo Jung Lee | 2014 | Korean | miR-196a(rs11614913) | Early Breast cancer | 452 | OS; DFS | (42) |
| Won Hee Kim | 2012 | Korean | mir-146a(rs2910164); miR-149(rs2292832); miR-196a2(rs11614913); miR-499(rs3746444) |
HCC | 67 | OS | (47) |
| Xia Lingzi | 2016 | Chinese | mir-146a(rs2910164); miR-149(rs2292832); miR-196a2(rs11614913); miR-423(rs6505162); miR-608(rs4919510) |
NSCLC | 584 | OS | (46) |
| Xiao-Pin Ma | 2016 | Chinese | miR-608(rs4919510) | HCC | 362 | OS | (51) |
| Xiaoxiang Guan | 2013 | Chinese | mir-146a(rs2910164); miR-149(rs2292832); miR-196a2(rs11614913); miR-499(rs3746444) |
SCCOP | 281 | OS; DFS | (38) |
| Xi-Dai Long | 2016 | Chinese | miR-1268a (rs28599926) | HCC | 1,299 | OS; RFS | (35) |
| Xingming Chen | 2016 | Chinese | mir-146a(rs2910164); miR-196(rs11614913); miR-423(rs6505162); miR-492(rs2289030) |
SCCOP | 1,008 | DFS | (67) |
| Yang Zhao | 2014 | American | mir-182(rs129197463); miR-4302(rs11048315); miR-4422(rs17111728); miR-4741(rs7227168); miR-4742(rs7522956); miR-5197(rs2042253); miR-612(rs550894) |
NSCLC | 452 | OS | (61) |
| Yanhua Wu | 2017 | Chinese | miR-218 (rs11134527); miR-219-1(rs213210); miR-34b/c(rs4938723); miR-938(rs2505901) |
GC | 735 | OS | (66) |
| Yee Soo Cha | 2013 | Korean | miR-146a(rs2910164) | CRC | 343 | RFS | (43) |
| Yong-ping Mu | 2012 | Chinese | miR-30c (rs928508) | GC | 92 | OS | (54) |
| Z.Y. Sui | 2016 | Chinese | let-7 (rs10877887) | HCC | 89 | OS | (26) |
| Zhibin Hu | 2008 | Chinese | mir-146a(rs2910164); miR-149(rs2292832); miR-196a2(rs11614913); miR-499(rs3746444) |
NSCLC | 663 | OS | (34) |
| Zhibin Hu | 2011 | Chinese | let-7a-2(rs629367); miR-1–2(rs9989532); miR-125b(rs2241490); miR-145(rs353291); miR-193b(rs30236); miR-29c(rs2724377); miR-30c-1(rs928508); miR-367(rs13136737); miR-378(rs1076064) |
NSCLC | 923 | OS | (28) |
| Ying Li | 2016 | Chinese | let-7a-1(rs10739971) | GC | 334 | OS | (52) |
| Shizhi Wang | 2014 | Chinese | miR-107 (rs2296616); miR-107(rs78591545); miR-107(rs11185777) |
GAC | 940 | OS | (29) |
| JAEJOON LIM | 2018 | Korean | miR-196a(rs1614913) | Brain cancer | 179 | OS | (69) |
| Na Cao | 2018 | Chinese | miR-379(rs61991156) | GC | 217 | OS | (70) |
| Marta Kotlarek | 2018 | Polish | miR-146(rs2910164) | PTC | 315 | OS | (71) |
HCC, hepatocellular carcinoma; NSCLC, non-small cell lung cancer; GC, gastric cancer; GAC, gastric adenocarcinoma; SCCOP, squamous cell carcinoma of the non-oropharynx; CRC, colorectal cancer; ESCC, esophageal squamous cell carcinoma; HNSCC, head and neck squamous cell carcinoma; OSCC, oral squamous cell carcinoma; PTC, papillary thyroid carcinoma.