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. 2018 Dec 13;9:1059. doi: 10.3389/fneur.2018.01059

Figure 3.

Figure 3

SNX27 haploinsufficiency increases axon regeneration after SCI. (A) Overview of BDA-labeled nerve fibers (green) in horizontal sections of Snx27+/+ mice and Snx27+/− mice dorsal columns, ranging from rostral 1,500 μm (−1,500 μm) to caudal 2,000 μm (+2,000 μm) around the LC, Scale bar = 200 μm. R-C, Rostral–caudal; R-L, right–left. Dashed lines indicate the lesion center (LC). (B,B′,C,C′,D,D′) Higher magnification of the boxed areas in A. Arrowheads indicate BDA-labeled nerve fibers. Scale bar = 100 μm. (E) Quantification of BDA-labeled nerve fibers crossing the lesion site. n = 8 mice per genotype. Values are expressed as mean ± SEM and data were evaluated by One-way ANOVA with Tukey post-hoc test. **p < 0.01, ***p < 0.001. LC, Lesion Center.