Fig. 2.

Determination of the effect of pre-treatment with the selective V_1a receptor antagonist, SR49059 (1 mg/kg), or the selective oxytocin receptor antagonist, L-368,899 (2 mg/kg), according to the experimental protocol shown in a on b the cumulative locomotor ambulatory counts, and c the change in body temperature (°C) over 90 min following injection of oxytocin (OXY, 0.3 mg/kg. s.c., administered 15 min after the antagonist) or vehicle (VEH, 1 ml/kg saline). Data are presented as mean ± SEM, n = 12 per treatment (within-subjects design). In b **P < 0.01 from VEH + VEH controls. In c * P < 0.05 and *** P < 0.001 from VEH + VEH controls, ⁺ P < 0.05, ⁺⁺ P < 0.01 and ⁺⁺⁺ P < 0.001 0.03 mg/kg OXY from 0.3 mg/kg OXY and ^###P < 0.001 0.1 mg/kg OXY from 0.3 mg/kg OXY, following Tukey’s post hoc test