Fig. 2.

Activation of VTA-GABA neurons regulate incentive cue (IC) task performance. All data are shown as mean ± SEM. a Response ratio and accuracy significantly decreased, and latency to nosepoke and enter reward cup significantly increased after systemic CNO in rats expressing hM3D compared to saline and rats expressing GFP. b Intra-NAc injections of CNO had no effect on IC performance across the behavioral metrics, in either hM3D or GFP expressing rats. Asterisks represent significant differences determined by a Holms-Sidak post hoc test (*p < 0.05, **p < 0.01, ***p < 0.001)