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. 2018 Dec 19;9:5395. doi: 10.1038/s41467-018-07810-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Serum exosomal miR-25-3p is associated with CRC metastasis. a RT-PCR analysis of miR-25-3p level in circulating exosomes from healthy donor or CRC patients (12 cases of healthy donors, 36 cases of patients without metastasis, 15 cases of patients with metastasis). **P < 0.01 according to two-tailed Student’s t test. b Fold change of miR-25-3p in circulating exosomes from 20 CRC patients after surgical resection of CRC tissues. The expression of miR-25-3p in circulating exosomes from CRC patients at post-operation stage was normalized to 1. c Spearman correlation analysis between miR-25-3p levels in CRC tissues and miR-25-3p levels in circulating exosomes from CRC patients. Pearson’s correlation coefficient (r) and P-value are shown, n = 23. P-value is from Spearman’s test. d Spearman correlation analysis between miR-25-3p expression and KLF2, KLF4 expression in CRC tissues. Pearson’s correlation coefficient (r) and P-value are shown. P-value is from Spearman’s test. Scale bar represents 50 µm. e Schematic diagram of the role of CRC-secreted miR-25-3p in pre-metastatic niche formation