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. 2018 Dec 19;9:5381. doi: 10.1038/s41467-018-07797-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Model of interspersed helical sliding and hopping on DNA. The protein trajectory (blue trace) is confined within the radial electrostatic field (red to white) surrounding the DNA (green) to achieve rapid reassociation to DNA and efficient target localization during DNA scanning. Number of turns and length of hopping steps are unknown parameters and not to scale in this scheme