Table 3. Clinical profiles of RB patients with different types of germline RB1 mutations.

Mutation type	Number of probands	Mean age at diagnosis months (±SEM)	Number of probands by lateral type
			Unilateral	Bilateral
Nonsense#	9 (28%)	7.3 (2.5)	1	8
Splicing##	7 (25%)	11.9 (3.7)	2	5
Frameshift#	4 (13%)	16.5 (10.9)	1	3
Missense##	3 (9%)	3.7 (1.5)	1	2
Promoter##	3 (9%)	21.0 (4.0)	2	1
Gross deletion	5 (16%)	17.4 (6.4)	2	3
Total	31		9	22

Mean age at diagnosis is not different among patients with different types of mutations by One-way ANOVA. Laterality is not associated with mutation types (testing for patients with mutations that resulted in premature stop codon: ^#nonsense and ^#frameshift mutations versus patients with ^##splicing mutations combined with those with ^##missense and with ^##promoter mutations by Fisher’s exact test).