Table 2.

Molecular mimicry and immunodominant epitopes of human pyruvate dehydrogenase E2 subunit (PDC‐E2) 155–185*

Human PDC‐E2	KVGEKLSEGDLLAEIETDK*ATIGFEVQEEGY
B cell	KVGEKLSEGDLLAEIETDK*ATIGFEVQEEGY
CD4+ T cell	KVGEKLSEGDLLAEIETDK*ATIGFEVQEEGY
CD8+ T cell	KVGEKLSEGDLLAEIETDK*ATIGFEVQEEGY
E. coli PDC‐E2**	K-G--------L-EIETDK----------G-
Novosphingobium aromaticivorans PDC‐E2	--------GD-LAEIETDKAT--FE---EG-

^*K denotes ¹⁷³lysine which is the attachment site of lipoic acid (LA). The epitope recognized by each cell type is underlined.

^**ExDK sequence was preserved in both human and Escherichia coli PDC‐E2.