Figure 1.

Genetic absence of signal transducer and activator of transcription 6 (STAT6) or interleukin (IL‐10) affects the development of collagen‐induced arthritis (CIA) in DBA/1 mice. Circles, triangles and rectangles represent type‐II collagen (IIC)‐immunized wild‐type (WT), STAT6 knock‐out (KO) and IL‐10 KO mice, respectively. Data are expressed as the mean ± standard deviation (s.d.) of total scores for four limbs (a) or total number of arthritic paws (thickness ≥ 2·2 mm) for each mouse (b). *P < 0.05 and **P < 0.01, respectively (Mann–Whitney U‐test). The combined results of four independent experiments are shown.