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. 2018 Dec 7;9:2891. doi: 10.3389/fimmu.2018.02891

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Copyright © 2018 Djokic, Primus, Akoolo, Chakraborti and Parveen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B. microti (Bm) infection causes enlargement of the spleen in both young and old C3H mice at acute phase of infection. (A) Spleen weights of Bm infected and coinfected mice showed a significant increase over spleens of N40 infected mice on 11th day of infection in young mice, and (B) on 17th (pre-peak parasitemia) day of infection in 30 weeks old mice. Each bar represents the mean ± s.d. (^*p < 0.01, ^***p < 0.001, ^****p < 0.001). (C–F) H & E stained spleen sections showed erosion of marginal zone (arrow 2) between white (arrow 1) and red pulp (arrow 3) regions in B. microti infected (C) young, and (E) old mice. Disruption of marginal zone was found to have progressed more significantly in coinfected (D) young, and (F) old mice at this stage of infection, resulting in the absence of clear demarcation between red and white pulp in these (D,F) mice. Bar in microscopic images represents 100 μm.